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Spin-offs are a key factor for the successful transfer of promising technologies, research results and know-how to industry and society. Since 1988, the German Research Center for Artificial Intelligence has been encouraging ambitious researchers to set up their own companies and actively supporting them in doing so. Thus, over 100 spin-offs with more than 2500 jobs have emerged from the DFKI so far. More than half of these are currently active as independent companies. Many others have been taken over by established companies and enrich their product portfolios with innovative AI technologies from DFKI.